Houston Astros vs Seattle Mariners Prediction (Sep 22, 2026) | Predicted Sports
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Upcoming · Tue, Sep 22, 2026 · 9:40 PM ET · T-Mobile Park
HOU logo
Houston Astros
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SEA logo
Seattle Mariners
Latest line SEA 57% (no-vig) · O/U 7.5 O 50%
The AI field reports on game day, about three hours before first pitch.